If you face this error on OTRS / Znuny, you have very probably a missconfigured mail fetching configuration. You may face errors like:
IMAPS: Can't fetch email x from xxxx@xxxxx.xxx/xxx.xxxxx.xxx. Email too big (41234 KB - max 25600 KB)
or
POPS: Can't fetch email x from xxxx@xxxxx.xxx/xxx.xxxxx.xxx. Email too big (41234 KB - max 25600 KB)
To fix this, read this following article which explains how to setup a bigger e-mail size:
Configure max fetching size of e-mails in OTRS / Znuny
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